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br Materials and methods br Results Dried leaves
2024-11-27
Materials and methods Results Dried CGP 35348 receptor used were 48.46 g C. benghalensis, 857.98 g T. zebrina and 25.09 g T. fluminensis. The samples gave 12.9% C. benghalensis, 0.078% T. zebrina and 3.06% T. fluminensis methanol extracts. The methanol extracts were evaluated for their lipoxy
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Another heroic set of studies combining retrodialysis with
2024-11-27
Another heroic set of studies combining retrodialysis with electrophysiological recording at two distinct brain sites further indicated that the estradiol-induced increase in auditory-evoked firing in NCM also enhanced the selectivity of auditory-evoked responses in the downstream sensorimotor nucle
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Antioxidative enzymes such as SOD and CAT play prominent
2024-11-27
Antioxidative enzymes such as SOD and CAT play prominent roles in protecting against oxidative stress and extending food freshness due to their ability in scavenging active oxygen species for maintaining cell membrane integrity. Evidence shows that activities of SOD and CAT are positively affected
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A next series of experiments explored whether
2024-11-27
A next series of experiments explored whether cardiac Ampkα1 fccp is modified in response to pressure overload imposed by TAC. As a result, 2weeks of TAC treatment significantly increased Ampkα1 protein abundance in cardiac tissue from Ampkα1+/+ mice as compared to sham treated mice (Fig. 6A). In c
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Although the gene that encodes
2024-11-27
Although the gene that encodes DHFR has been strongly conserved during evolution, subtle differences in the active sites of bacterial, human and parasite NS 1738 have been exploited to develop DHFR inhibitors specific to particular pathogens 1, 3. For example, pyrimethamine and cycloguanil bind str
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br Polymorphic variation ERAP is
2024-11-26
Polymorphic variation ERAP1 is polymorphic and several single nucleotide polymorphisms (SNPs) in its gene that encode amino dapagliflozin changes have been associated with predisposition to a variety of diseases, ranging from viral infections to cancer and autoimmunity (Alvarez-Navarro and Lopez
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br Experimental section br Abbreviations PSA
2024-11-26
Experimental section Abbreviations PSA, puromycin–sensitive aminopeptidase; APN, aminopeptidase N; AML, acute myeloid Leukemia; ALL, acute lymphoblastic leukemia; AADR, amino phospholipase a2 inhibitor deprivation response; PAN, puromycin aminonucleoside; DCC, dicyclohexyl carbodiimide; NHS,
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Fmoc-Arg(Pbf)-OH With regard to the correlation between rear
2024-11-26
With regard to the correlation between -rearrangements and thromboembolic events, Zer et al. reported a VTE rate of 36% in a cohort of 98 patients with ALK-positive NSCLC. Of note, VTE was also associated with shorter overall survival (HR: 5.71, =0.01) . Only few others have investigated NSCLC drive
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Ketogenic diets are more effective in promoting weight loss
2024-11-26
Ketogenic diets are more effective in promoting weight loss than conventional caloric restriction [26] however, their effect on hepatic glucose and lipid metabolism remains inconclusive. Blood glucose homeostasis is tightly regulated. In both mice and humans consuming KD, baseline blood glucose decr
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Liver plays a pivotal role in metabolism of
2024-11-26
Liver plays a pivotal role in metabolism of xenobiotic compounds, such as environmental contaminants and drugs. Some of these compounds generate hepatic damage and impair its function. It was well-known that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) could induce pathological changes in mouse and ra
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Two patients developed diffuse mesangio proliferative glomer
2024-11-26
Two patients developed diffuse mesangio-proliferative glomerulonephritis (DMPG) postoperatively, presenting as nephrotic syndrome and benign haematuria, respectively. DMPG has been reported in an adult patient with thymomatous MG following thymectomy [35], and various types of glomerulonephritis hav
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In earlier experiments on snails a behavioral model
2024-11-26
In earlier experiments on snails, a behavioral model was employed of certain food rejection to study the mechanisms of the reconsolidation of long-term associative memory. It was found that conditioned food stimuli (reminder) presentation, combined with injections of NMDA glutamate receptor antagoni
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Prostate cancer is the second leading cause of
2024-11-26
Prostate cancer is the second leading cause of cancer-related death in men in the United States [25]. Similar to pancreatic cancer, prostate cancer has few diagnostic options available, particularly to differentiate indolent from aggressive disease. Axl is also overexpressed in ∼50% of prostate canc
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br Studies in zebrafish vascular
2024-11-26
Studies in zebrafish: vascular and neural development and the regulation of left–right asymmetry Zebrafish embryos represent an excellent model system to examine vertebrate vascular development. Major advantages of the zebrafish system include its genetic tractability, small size, external fertil
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br Introducing toll like receptors TLRs are
2024-11-25
Introducing toll like receptors TLRs are the most important receptors which are expressed on the cytoplasmic and internal vesicles membrane. They have a similar structure including a leucine-rich repeats (LRRs) domain which is out of ras gtpase membrane, a hydrophobic transmembrane and a toll/int
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