Harnessing Pregnenolone Carbonitrile: Mechanistic Insight...
2025-10-18
Pregnenolone Carbonitrile (PCN) is more than a canonical rodent PXR agonist—its capacity to modulate cytochrome P450 activity, hepatic stellate cell trans-differentiation, and water homeostasis positions it as a keystone molecule in the translational research of xenobiotic metabolism, liver fibrosis, and beyond. This thought-leadership article bridges mechanistic understanding and experimental strategy, highlighting new findings that connect PXR activation with hypothalamic AVP expression, and offering practical guidance for leveraging PCN in preclinical and translational contexts.